Section: New Results

Multi-scale model of the CD8 T cell immune response

We presented in [21] the first multi-scale model of CD8 T cell activation in a lymph node, following an acute infection. CD8 T cell dynamics are described using a cellular Potts model (hence cells are discrete interacting objects), whereas intracellular regulation is associated with a continuous system of nonlinear ordinary differential equations focusing on the dynamics of key proteins. This model allows to reproduce the dynamics of CD8 T cells over a five days period (corresponding to the activation and differentiation into effector cells) and is currently used to characterize the generation of memory cells.